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1519

1519: A devastating smallpox epidemic decimated the surviving Taino population across the Greater Antilles.

1519: A devastating smallpox epidemic decimated the surviving Taino population across the Greater Antilles. During this same year, a cacique named Enriquillo led his encomienda into the interior mountains to successfully maintain their independence from Spanish rule.

Source  ·  p. 158 Rouse, The Tainos, 158